{"id":14269,"date":"2021-05-07T09:28:05","date_gmt":"2021-05-07T07:28:05","guid":{"rendered":"https:\/\/www.m-q.ch\/?p=14269"},"modified":"2021-05-10T14:07:55","modified_gmt":"2021-05-10T12:07:55","slug":"covid_19_biomarqueur","status":"publish","type":"post","link":"https:\/\/www.m-q.ch\/fr\/covid_19_biomarqueur\/","title":{"rendered":"Covid-19 : D\u00e9tecter les formes graves de la maladie \u00e0 un stade pr\u00e9coce"},"content":{"rendered":"
\"Biomarqueur\"
Un patient avec un covid 19 s\u00e9v\u00e8re est intub\u00e9 dans l'unit\u00e9 de soins intensifs. (Image : iStock.com\/Tempura) UZH<\/figcaption><\/figure>\n

La plupart des personnes infect\u00e9es par le virus Sars-CoV-2 ne tombent pas malades ou ne deviennent pas gravement malades. Certains patients, cependant, d\u00e9veloppent une maladie covid-19 tr\u00e8s grave, mettant leur vie en danger. Ils n\u00e9cessitent des soins m\u00e9dicaux intensifs et la respiration artificielle, comme l'\u00e9crit l'Universit\u00e9 de Zurich (UZH) dans un communiqu\u00e9 de presse. Pour les personnes touch\u00e9es, l'infection est souvent fatale ou entra\u00eene des cons\u00e9quences consid\u00e9rables sur la sant\u00e9 \u00e0 long terme. Afin d'identifier ces patients \u00e0 un stade pr\u00e9coce et de les traiter rapidement, il est n\u00e9cessaire de disposer d'indicateurs mesurables : des biomarqueurs pr\u00e9dictifs qui peuvent \u00eatre utilis\u00e9s pour pr\u00e9voir le risque d'une \u00e9volution grave de la maladie.<\/p>\n

\u00a0<\/strong>Des biomarqueurs pour les cours de covid 19 s\u00e9v\u00e8res d\u00e9couverts pour la premi\u00e8re fois<\/strong><\/p>\n

L'\u00e9quipe dirig\u00e9e par Burkhard Becher, professeur \u00e0 l'Institut d'immunologie exp\u00e9rimentale de l'Universit\u00e9 de Zurich, ainsi que des chercheurs de T\u00fcbingen, Toulouse et Nantes, ont maintenant d\u00e9couvert un tel biomarqueur : le nombre de cellules T tueuses naturelles dans le sang. Ils constituent une cat\u00e9gorie de globules blancs et font partie du syst\u00e8me de d\u00e9fense immunitaire pr\u00e9coce. \"Sur la base du nombre de lymphocytes T tueurs dans le sang, il est possible de pr\u00e9dire avec un degr\u00e9 de certitude \u00e9lev\u00e9 l'\u00e9volution de la covidie 19, et ce d\u00e8s le jour de l'admission \u00e0 l'h\u00f4pital\", explique M. Becher.<\/p>\n

Une th\u00e9rapie plus cibl\u00e9e gr\u00e2ce \u00e0 une immunopathog\u00e9nie plus pr\u00e9cise<\/strong><\/h4>\n

Le nouveau test de d\u00e9tection permet de d\u00e9cider des mesures organisationnelles et th\u00e9rapeutiques \u00e0 prendre pour un patient atteint du Covid 19, telles que le transfert en soins intensifs ou en service normal, la fr\u00e9quence des mesures de la saturation en oxyg\u00e8ne, la th\u00e9rapie et le d\u00e9but du traitement. \"Pour de telles consid\u00e9rations, les biomarqueurs pr\u00e9dictifs sont tr\u00e8s utiles. Ils contribuent \u00e0 fournir les meilleurs soins possibles aux patients souffrant de cours s\u00e9v\u00e8res\", d\u00e9clare Stefanie Kreutmair. Les r\u00e9sultats permettraient \u00e9galement d'explorer de nouvelles th\u00e9rapies contre le covid-19, selon le premier auteur de l'\u00e9tude.<\/p>\n

Des progr\u00e8s gr\u00e2ce \u00e0 la haute technologie<\/strong><\/p>\n

La cause de la d\u00e9t\u00e9rioration rapide des patients du Covid 19 est une r\u00e9ponse excessive du syst\u00e8me immunitaire, a-t-il d\u00e9clar\u00e9. \"L'\u00e9norme production de substances messag\u00e8res appel\u00e9es cytokine storm provoque une r\u00e9ponse inflammatoire massive dans le corps. Les cellules immunitaires migrent en masse dans les poumons, o\u00f9 elles perturbent les \u00e9changes gazeux\", explique M. Becher. Pour d\u00e9terminer les cellules immunitaires et les cytokines pr\u00e9sentes dans les \u00e9chantillons des patients, les chercheurs de l'UZH ont utilis\u00e9 la cytom\u00e9trie \u00e0 haute dimension. Cela permet de d\u00e9terminer simultan\u00e9ment et au niveau de la cellule unique les prot\u00e9ines pr\u00e9sentes \u00e0 la surface et \u00e0 l'int\u00e9rieur de millions de cellules, puis de les traiter par des algorithmes informatiques.<\/p>\n

D\u00e9chiffrage de la signature immunitaire sp\u00e9cifique du Sars-CoV-2<\/strong><\/h4>\n

Outre le Sars-CoV-2, de nombreux autres agents pathog\u00e8nes peuvent provoquer une pneumonie - et donc une r\u00e9ponse immunitaire, comme le souligne l'UZH. La r\u00e9ponse immunitaire des patients du Covid 19 a d\u00e9j\u00e0 fait l'objet d'\u00e9tudes intensives, mais jusqu'\u00e0 pr\u00e9sent, on ne savait pas exactement ce qui caract\u00e9rise la r\u00e9ponse immunitaire sp\u00e9cifique au Sars-CoV-2. Pour le d\u00e9terminer, les chercheurs ont \u00e9galement analys\u00e9, \u00e0 titre de comparaison, des \u00e9chantillons de sang de patients atteints de pneumonie s\u00e9v\u00e8re d\u00e9clench\u00e9e par des agents pathog\u00e8nes autres que le nouveau coronavirus. L'UZH ajoute : \"La comparaison de la r\u00e9ponse immunitaire des patients Covid-19 avec celle du groupe de comparaison a permis d'identifier ce qui est unique dans la r\u00e9ponse immunitaire au Sars-CoV-2.<\/p>\n

\"Les r\u00e9ponses immunitaires dans les diff\u00e9rentes inflammations pulmonaires sont tr\u00e8s similaires et font partie d'une r\u00e9ponse inflammatoire g\u00e9n\u00e9rale souvent observ\u00e9e chez les patients en soins intensifs. Cependant, les cellules T et les cellules tueuses naturelles se comportent de mani\u00e8re unique dans le Covid-19 et d\u00e9finissent une sorte de mod\u00e8le dans le syst\u00e8me immunitaire : la signature immunitaire sp\u00e9cifique au Covid-19\", explique Becher.<\/p>\n

Litt\u00e9rature : Stefanie Kreutmair, Susanne Unger, Nicol\u00e1s Gonzalo N\u00fa\u00f1ez, Florian Ingelfinger, et. al. Des signatures immunologiques distinctes distinguent la pneumonie critique s\u00e9v\u00e8re du COVID-19 de celle qui n'est pas due au SRAS-CoV-2. Immunit\u00e9 (sous presse (PDF, 7 MB)<\/a>disponible en ligne \u00e0 partir du 10 mai 2021).<\/em><\/p>\n

 <\/p>\n

Autres questions relatives \u00e0 la Covid 19 : <\/em><\/strong><\/p>\n

Les eaux us\u00e9es d\u00e9couvrent \u00e9galement de nouvelles mutations coronales<\/a><\/em><\/p>\n

Le risque de Covid 19 augmente avec le nombre de pollens<\/em><\/a><\/p>","protected":false},"excerpt":{"rendered":"

La plupart des personnes infect\u00e9es par le Sras-CoV-2 ne tombent pas malades ou ne pr\u00e9sentent aucune gravit\u00e9. En revanche, une partie des patients d\u00e9veloppent une maladie Covid-19 tr\u00e8s grave et potentiellement mortelle. Ils doivent b\u00e9n\u00e9ficier d'une prise en charge m\u00e9dicale intensive et d'une respiration artificielle, comme le pr\u00e9cise l'Universit\u00e9 de Zurich (UZH) dans un communiqu\u00e9 de presse. Pour les personnes concern\u00e9es, l'infection est souvent fatale ou entra\u00eene des [...].<\/p>","protected":false},"author":35,"featured_media":14271,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[4448],"tags":[4952,4281,4836],"class_list":["post-14269","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-allgemein","tag-biomarker","tag-covid-19","tag-sars-cov-2"],"acf":[],"yoast_head":"\nCovid-19: Schwere Verl\u00e4ufe fr\u00fchzeitig entdecken - MQ Management und Qualit\u00e4t<\/title>\n<meta name=\"description\" content=\"Schwere Verl\u00e4ufe von Covid-19: Die Universit\u00e4t Z\u00fcrich hat den ersten Biomarker identifiziert, der zuverl\u00e4ssige Voraussagen erm\u00f6glicht.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.m-q.ch\/fr\/covid_19_biomarqueur\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Covid-19: Schwere Verl\u00e4ufe fr\u00fchzeitig entdecken - 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